Septrin
or co- trimoxazole is an antibacterial formulation and so is used to treat
bacterial infections caused by susceptible organisms.
Such infections include
urinary tract infections, respiratory tract infections like infected
bronchitis, pneumonia, infections in cystic fibrosis, otitis media and
intra-abdominal infections such as typhoid fever.
However,
it is not all bacteria that are susceptible to the drug. The right thing to do
when you have any of such infections is to consult a clinician who will
prescribe a microbial culture and sensitivity (MCS) test to ascertain what
organism is responsible for the infection and to which antibiotic it is
sensitive before prescribing such drug; though empirical treatment may commence
while awaiting the test result.
Recently,septrin has been found to boost the immunity of HIV/AIDS
patients, thereby improving their resistance to infections. The exact mechanism
of this effect is not well known but the drug has become part of the routine
therapy for such patients. Nevertheless, such use must be under the supervision
of the attending clinician since the drug may interact with some antiretroviral
agents.
Prolonged
use of septrin can cause liver problems and kidney problems especially
if not taken with enough water or in a dehydrated or renal impaired patient as
the drug can crystallise and accumulate in the kidneys.
Other
important adverse effects of septrin are hypersensitivity or allergic reactions
which include rash, toxic epidermal necrosis, systematic lupus erythematosis
and Stevens-Johnson syndrome. Although these reactions are rare, they usually
have devastating effects when they occur.
Septrin can also cause some form of blood disorders especially in patients with
already existing blood cell problems, ( for example sickle cell patients and those
with G6PD deficiency).
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