The effect of diet on the unborn child is not only a vital area of
study, but it is also an incredibly complex one. A recent study delves into the
mechanisms behind omega fatty acids and the development of the fetal brain.
A new study, published in journal Stem Cells, shows that consuming
the right ratio of essential fatty acids is key during pregnancy.
The importance of diet during pregnancy is clear and needs no
in-depth explanation.As the baby develops, it needs access to all the
components necessary to build an entire functioning human.Because the
development of the brain is largely completed during its stay in the womb, the
impact of any dietary deficits is likely to be more significant than for other
organs.
A recent study carried out at Tohoku University’s School of
Medicine in Japan looked at the role of dietary fatty acids – omega-6 and
omega-3 – in the developing fetuses of rats.
The
importance of omega acids is well documented, but this latest study, led by
Prof. Noriko Osumi, delved into the specific mechanisms involving fatty acids
during the development of the embryo’s brain.
Both omega-3 and omega-6 are referred to as essential fatty acids
because they cannot be generated by the body itself; they must, therefore, be
taken in through the diet.
The roles of omega oils in the body include the storage of energy,
oxygen transport, functioning of cell membranes and inflammation regulation.
Omega-3 oils are predominantly found in marine fish. The most
common forms are docosahexaenoic acid and eicosapentaenoic acid. In the US,
because of the relatively low level of fish in the diet, these oils are often
not consumed in adequate quantities.
Previous research has demonstrated the importance of omega-3
during pregnancy. It plays a role in determining the length of gestation and in
staving off depression before and after birth.
Omega-3 oils have also been shown to increase the rate of brain
growth in the fetus and throughout the first year of life. These oils are
particularly important in the development of the eye. Animal fetuses deprived
of omega-3 show marked visual and behavioral changes that cannot be rectified
by healthy diets after birth.
Osumi and his team wanted to look at the effect of a change in
ratios of omega oils. By feeding pregnant rats a diet rich in omega-6 and poor
in omega-3, they mimicked the ratios found commonly in diets around the world
today.Omega-6 is more commonly found in seed oils, and omega-3 is almost
exclusively found in fish.
Once the rat mothers had given birth, the team found that the
brains of the offspring with the omega-6-rich/omega-3-poor diets were
significantly smaller than those whose mothers had consumed a more balanced
diet with equal amounts of 3 and 6.
Interestingly, and perhaps worryingly if we are to extrapolate the
findings, the rat offspring subjected to the skewed dietary ratios in the womb
also exhibited changes in emotional behaviour.
The offspring of the low omega-3 mothers showed increased anxiety
in adulthood, despite having been supplied with a healthy diet from birth.
Omega-based changes
Omega-based changes
Similar deficits have been demonstrated in previous studies, but
Osumi and his colleagues delved into the mechanisms behind the findings to see
what specific changes occurred during the development of the fetal brain under
such conditions.
The team performed the first comprehensive measurement of lipid
metabolites in the developing brain; they identified that metabolites of omega
oils are vital regulators of neural stem cells – the cells that go on to
develop into fully fledged brain cells.
In the rats with diets heavier on the omega-6 than 3, the neural
stem cells developed more rapidly, to their detriment. The results, published
in the journal Stem Cells, show that increased levels of omega-6 produce an
increase in omega-6 oxides. These omega offshoots cause premature aging of
fetal neural stem cells.
The study’s authors conclude: “These findings provide compelling evidence that excess maternal consumption of omega-6 combined with insufficient intake of omega-3 causes abnormal brain development that can have long-lasting effects on the offspring’s mental state.”
The study’s authors conclude: “These findings provide compelling evidence that excess maternal consumption of omega-6 combined with insufficient intake of omega-3 causes abnormal brain development that can have long-lasting effects on the offspring’s mental state.”
The general recommendation is that omega-6 and omega-3 should be
consumed at a 1:1 ratio, but it is not uncommon for some American diets to be
as skewed as 16:1. A general fear of mercury poisoning is often cited as a
reason to reduce the amount of marine fish eaten.
Source: ngrguardiannews
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