Preventing enzymes in hair follicles promotes hair growth

Blocking of enzymes inside hair follicles that are suspended in a resting state restores hair growth, a new study from researchers at Columbia University Medical Center has found.
In experiments with mouse and human hair follicles, Angela M. Christiano, PhD, and colleagues found that drugs that inhibit the Janus kinase (JAK) family of enzymes promote rapid and robust hair growth when directly applied to the skin.
The study raises the possibility that drugs known as JAK inhibitors could be used to restore hair growth in multiple forms of hair loss such as that induced by male pattern baldness, and additional types that occur when hair follicles are trapped in a resting state. Two JAK inhibitors have been approved by the U.S. Food and Drug Administration. One is approved for treatment of blood diseases (ruxolitinib) and the other for rheumatoid arthritis (tofacitinib). Both are being tested in clinical trials for the treatment of plaque psoriasis and alopecia areata, an autoimmune disease that causes hair loss.
"What we've found is promising, though we haven't yet shown it is effective for male pattern baldness," said Dr. Christiano. "More work needs to be done to test formulations of JAK inhibitors specially made for the scalp to determine whether they can induce hair growth in humans."
Christiano and her colleagues serendipitously discovered the effect of JAK inhibitors on hair follicles when they were studying a type of hair loss known as alopecia areata, caused by an autoimmune attack on the hair follicles. Christiano and colleagues reported last year that JAK inhibitors shut off the signal that provokes the autoimmune attack, and that oral forms of the drug restore hair growth in some people with the disorder.
In the course those experiments, Dr. Christiano noticed that mice grew more hair when the drug was applied topically to the skin than when given internally. This suggested JAK inhibitors might have a direct effect on the hair follicles in addition to inhibiting the immune attack.
When the researchers looked more closely at normal mouse hair follicles, they found that JAK inhibitors rapidly awakened resting follicles out of dormancy. Hair follicles do not produce hair constantly but rather by cycling between resting and growing phases.
JAK inhibitors trigger the follicles' normal reawakening process, the researchers found. Mice treated for five days with one of two JAK inhibitors sprouted new hair within 10 days, greatly accelerating the hair follicle growth phase. No hair grew on untreated control mice in the same time period.

Enzymes can be prevented in the hairs by applying one of these two natural  products which is very popular in Asia.
Asian ladies like using natural mixtures packaged in the form of cream/oil to retain their hairs and its longevity.

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Blend of four oils in a bottle egg yolk oil- Egg oil helps recreate and maintains the texture of hair- an excellent natural hair nutrient for dry scalp, nourishes hair, natural softness.
Acts as a humectant drawing moisture in as it conditions.
Egg oil averts falling of hair, prevents premature graying and strengthens hair with regular use.
 It has superior nourishing and conditioning property which help in reducing the onset of premature hair loss.
 Egg oil also promotes the growth of new hair
REETHA OIL (Soap-nut tree) is well known for hair care & hair growth, also good for oily hair.
SIKAKAI means "fruit for hair". It is made from Acacia concinna, a shrub native to the warm, plains of central and south India. Acacia concinna has been used for hair care in India for centuries.
AMLA OIL: Regular use of amla strengthens the hair follicles, stimulates hair growth, keeps dandruff away, straightens your hair, prevents split ends and nourishes your hair. It also prevents premature graying of hair and stops hair loss.
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